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Ubiquinone Found to Be Best CoQ10 for Blood Pressure and Glucose



Preventable conditions like diabetes and hypertension (also known as high blood pressure) continue to present major health problems in America. The American Heart Association estimates that one in every three people has high blood pressure, while the Centers for Disease Control (CDC) estimates that one in every 11 people have diabetes. Worse yet, millions more have pre-diabetes, with blood sugar levels higher than normal, but not quite high enough to be considered diabetes.

While seemingly unrelated, diabetes and high blood pressure go hand-in-hand more than you’d think. In fact, cardiovascular disease is a major complication of type-2 diabetes.

Research shows that approximately 65 percent of people with diabetes die from heart attack or stroke. Similarly, diabetics are two to four times more likely to have heart disease or a stroke than those without diabetes.[1]

Ubiquinol vs. Ubiquinone: Which Form of CoQ10 is Best for Blood Pressure and Diabetes

Given the clear and very common connection between diabetes and heart disease, researchers set out to see if a specific form of the heart-healthy antioxidant CoQ10 could have an impact on both conditions.

Researchers have known for some time now that CoQ10 is beneficial for those with heart concerns or blood sugar imbalances, but less was known about which form was best. Ubiquinol is a form of CoQ10 with one more electron than its other form, ubiquinone, the form naturally made by the body. They are sort of different sides of the same CoQ10 coin, if you will, yet there has been much debate surrounding which form is preferred for those with heart health concerns.

Researchers gave two different forms of CoQ10—ubiquinol-10 and ubiquinone-10—to separate groups of diabetic rats, to determine if one might be more effective than the other against blood pressure and/or elevated glucose levels.

In the study, researchers looked at several factors in relation to the effectiveness of either form of CoQ10:

  • Oxidative stress markers, including reactive oxygen metabolites and malondialdehyde
  • Non-fasting blood glucose levels
  • Blood pressure
  • Bioavailability

Researchers Conclude Ubiquinone Best form of CoQ10 for Blood Pressure and Glucose Balance

Oxidative stress is a critical biomarker when it comes to diabetes, as both free radical damage and a decrease in antioxidant protection have been shown to contribute to and even increase the development of diabetes complications.

Researchers found that both blood glucose and blood pressure were decreased in those rats given the ubiquinone-10. This form also reduced oxidative stress and increased CoQ10 levels, as well as a liver coenzyme known as nicotinamide adenine dinucleotide phosphate (NADPH) coenzyme Q reductase.

The ubiquinol-10 form also eased oxidative stress and increased CoQ10 levels. However, this form was found to be better absorbed in the liver and pancreas than ubiquinone-10, though researchers were quick to point out that both were similarly effective.

Given the results of the study, the ubiquinone form of CoQ10 appears to be the more well-rounded of the two.

The CoQ10 Connection: Don’t Wait Until It’s Too Late!

Coenzyme Q10 (CoQ10) has long been studied for its cardiovascular protection, ranging from artery support, healthy muscular function of the heart, good pumping action, and maintaining a strong heart overall.[2-9] When it comes to blood pressure specifically, study after study shows that CoQ10 works to significantly lower blood pressure, even in people with hypertension and, yes, type-2 diabetes.[10-16]

The health complications that can stem from either preventable condition present too much risk to ignore. Diabetes alone has a whole host of debilitating side effects. In addition to affecting mood, sexual function, oral health, digestion, and wound healing, diabetes also increases your risk for:[17]

  • Blindness (diabetic retinopathy)
  • Nerve damage (diabetic neuropathy)
  • Kidney failure
  • Stroke
  • Heart disease
  • High blood pressure

Clearly CoQ10 is a safe and effective treatment for people with diabetes who are looking to not only lower blood sugar levels, but also to protect their cardiovascular systems, particularly when it comes to free radical damage and blood pressure.

In both forms, long-term supplementation appeared to be safe. Aim for 200-400 mg of CoQ10 as ubiquinone per day for optimal heart health.



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  16. Singh RB, et al. J Hum Hypertens. 1999;13:203-8. Prangthip P, et al. J Diet Suppl. 201

Kimberly Day Kimberly Day has spent the past 15 years uncovering natural and alternative health solutions. She was the managing editor for several of the world’s largest health newsletters including those from Dr. Susan Lark, Dr. Julian Whittaker and Dr. Stephen Sinatra. She has also penned several health-related newsletter and magazine articles, co-authored the book the Hormone Revolution with Dr. Susan Lark, contributed articles to Lance Armstrong’s consumer site, and created a number of health-related websites and blogs.

For tips, tools and strategies to address your most pressing health concerns and make a positive difference in your life, visit Peak Health Advocate.

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