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Take This Vitamin to Boost Effectiveness of Curcumin for Brain Health


Curcumin New hope is now offered by scientists from the University of California publishing in the Journal of Alzheimer’s Disease, as they have identified the specific intracellular mechanism regulated by vitamin D3 that may help the body clear the brain of amyloid beta.

There has been scant evidence in the past to show that vitamin D and the curry-derived compound, curcumin help to prevent Alzheimer’s dementia. Researchers now provide solid research-based science to explain the precise pathway used by these two natural substances to help stimulate the immune system to activate key genes involved in clearing the amyloid-beta protein.

Vitamin D3 and Curcumin Work Together to Clear Deadly Brain Plaques

Chief study author, Dr. Milan Fiala noted, “This new study helped clarify the key mechanisms involved, which will help us better understand the usefulness of vitamin D3 and curcumin as possible therapies for Alzheimer’s disease.” Prior research has suggested a synergistic effect between the two compounds and clearance of deadly protein tangles, but no action pathway has ever been postulated until now.

To test their hypothesis, scientists took blood samples from a group of currently diagnosed Alzheimer’s disease patients and a control group of healthy volunteers. They then isolated the immune-stimulating component of the white blood cells called macrophages. These special cells are known to target and eliminate amyloid fibrils and other waste products that accumulate in the brain before they manifest into detectable disease conditions.

Include Regular Sun Exposure or Supplement Vitamin D3 and Curcumin to Ward Off Mental Decline

Researchers then incubated some of the extracted immune cells for a 24 hour period in a solution containing the active form of vitamin D3 (1a, 25-dihydroxyvitamin D3). Other cells were exposed to a standardized curcumin extract. Past studies have shown that there are two types of macrophages, Type I and Type II that independently perform different functions, yet must work together to effectively remove amyloid protein in the brain.

The scientists found that Type I macrophage activity is greatly enhanced with optimal saturation of vitamin D3, and Type II immune cells are supported by the presence of curcumin. Researchers found that the action of both Type I and II macrophages are greatly enhanced by the synergistic application of vitamin D3 and curcumin together. Dr. Fiala concluded, “Our findings demonstrate that active forms of vitamin D3 (and curcumin) may be an important regulator of immune activities of macrophages in helping to clear amyloid plaques.”

The number of Alzheimer’s disease cases continues to grow at an unprecedented rate, threatening both the lives of those suffering from this dreaded illness and the health care system itself, as billions are spent to care for the millions suffering from this lifestyle-mediated disease.

Proof positive now exists to support maintaining optimal blood saturation levels (50 to 70 ng/mL) of vitamin D as measured using the simple and inexpensive 25(OH)D test. Most people will need to supplement with 5,000 to 7,000 IU of vitamin D3 per day or rely on sun exposure to obtain ideal levels. Adding curcumin to your regular diet using natural curry-enriched foods or supplementing (300 to 500 mg per day standardized to 95% total curcuminoids) will provide a synergistic effect shown to help clear brain tangles and prevent Alzheimer’s dementia.



John Phillip is a diet, health and nutrition researcher and writer with a passion for understanding weight loss challenges and encouraging health modification through natural diet, lifestyle and targeted supplementation. John’s passion is to research and write about the cutting edge alternative health technologies that affect our lives.

Discover the latest alternative health news concerning diabetes, heart disease, cancer, dementia and weight loss at My Optimal Health Resource

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6 responses to “Take This Vitamin to Boost Effectiveness of Curcumin for Brain Health”

  1. John Lightbourn says:

    There is a lot of talk right now about turmeric being difficult to absorb, the most you can expect is about 40%. is that true? And if so, what good is that to anyone?

    • Irving Weiss says:

      John the Turmeric issue has been addressed with the use of black pper. This combination makes the absorption better. The only question I have is why isn’t other pepper ingredients suggested to use.
      Cayenne and other spicy ingredients will probably help the flow of blood and oxygen to the brain.

  2. Ken Witte says:

    Do you have any recommendations for clearly cataracts naturally with supplementation?


  3. Robert Shaw says:

    I have been taking Turmeric ( circumin ) for many years and have found that it is great protection against most kinds of infections, especially hip and knee problems. I take 500 mg daily along with a one a day vitamin to help absorbion. I have no side effects with this level of useage. It seems to be efective on most any body disease. My doctor keeps asking where I get this nutrient from.